Abrocitinib

Abrocitinib is a drug to overcome moderate to severe atopic dermatitis that has not been successfully overcome with other treatments . Medicines available in the form of tablets can only be consumed with the recommendation of a doctor.

Abrocitinib is a JAK inhibitor ( janus kinase ) drug, which is a compound that plays an important role in the emergence of inflammatory reactions in eczema or atopic dermatitis. This medicine is intended for children over 12 years of age and adults.

Abrocitinib brand name: Freorla

Warnings Before Taking Abrocitinib

Abrocitinib should not be used indiscriminately. There are several things that need to be considered before consuming this medicine, namely:

• Tell your doctor about any allergies you have. Abrocitinib should not be consumed by people who are allergic to this drug.
• Tell your doctor if you are undergoing treatment with antiplatelets . Abrocinitip should not be used with drugs of this group, except for low-dose aspirin.
• Tell your doctor if you suffer from severe liver dysfunction or infectious diseases , including TB. Abrocinitip should not be consumed by patients with these conditions.
• Tell your doctor if you suffer from heart disease, kidney disease , liver disease, blood clotting disorder, immune system disorder, anemia , or cancer.
• Inform the doctor if you are undergoing treatment with immunosuppressant drugs and avoid close contact with patients with infectious diseases, because the use of abrocitinib can increase the risk of infection.
• Do not undergo immunization with a live vaccine during treatment with abrocitinib.
• Tell your doctor if you are pregnant, breastfeeding, or planning to become pregnant.
• Tell your doctor if you are using other medicines, including supplements and herbal products, to avoid unwanted drug interactions.
• See a doctor immediately if an allergic drug reaction or serious side effect occurs after consuming abrocitinib.

Dosage and Administration of Abrocitinib

The dosage and rules of use of abrocitinib will be determined by the doctor based on the patient’s age or condition. In general, the following are the doses of abrocitinib:

Condition: Atopic dermatitis

• Adults and children aged ≥12 years: 100 mg per day. If the patient’s body does not respond enough after 12 weeks of treatment, the dose can be increased to 200 mg per day.

How to Consume Abrocitinib Correctly

Follow your doctor’s advice and read the instructions on the packaging before consuming abrocitinib. Do not increase or decrease the dose without the doctor’s permission.

Abrocitinib can be taken before or after meals. Swallow the medicine with water. It is recommended that you consume abrocitinib regularly at the same time every day to maximize the treatment effect.

If you forget to take abrocitinib, take it as soon as you remember. However, if the distance with the next application schedule is less than 12 hours, ignore the missed dose and do not double the next dose.

Abrocitinib can make the skin more prone to sunburn. Therefore, use sunscreen and closed clothing when outdoors during the day. Contact your doctor if you experience severe sunburn during treatment with abrocitinib.

Because abrocitinib can lower the body’s resistance, you should avoid direct contact with people with infectious diseases, such as flu or chicken pox .

Store abrocitinib in a cool, dry place away from direct sunlight and out of the reach of children.

Abrocitinib Interactions with Other Drugs

The use of abrocitinib with certain drugs can cause drug interactions, such as:

• Increased risk of bleeding if used together with antiplatelet drugs, such as anagrelide .
• Increased risk of infection if used together with drugs that have an immunosuppressant effect, for example adalimumab or cilostazol.
• Increased risk of infection or reduced vaccine effectiveness if used with live vaccines, such as BCG
• Increased effectiveness of abrocitinib if used with fluconazole or fluvoxamine
• Decreased effectiveness of abrocitinib when used with rifampicin

To reduce the risk of drug interactions above, always consult with a doctor if you want to use abrocitinib with other drugs.

Side Effects and Dangers of Abrocitinib

Some side effects that may occur after consuming abrocitinib are:

• Cold symptoms, such as stuffy nose , runny nose, sneezing, sore throat
• Nausea or vomiting
• Headache or dizziness
• Acne
• Stomach ache
• Skin infection or rash

Check with your doctor if the side effects do not improve or even worsen. Immediately seek medical help if a drug allergic reaction or more serious side effect appears, such as:

• The appearance of unusual bleeding symptoms, such as bruising
• Pale skin, shortness of breath, and unusual tiredness
• Stroke or heart attack
• Symptoms of infection, such as fever , sweating, chills, muscle pain, and diarrhea

SOURCE :
Meher, BR, Mohanty, RR, & Padhy, BM (2022). Efficacy and Safety of Abrocitinib for the Treatment of Moderate-to-Severe Atopic Dermatitis: a Meta-Analysis of Randomized Clinical Trials. Journal of Dermatological Treatment, 33(4), pp. 2335–2343.Ferreira, S., Guttman-Yassky, E., & Torres, T. (2020). Selective JAK1 Inhibitors for the Treatment of Atopic Dermatitis: Focus on Upadacitinib and Abrocitinib. American Journal of Clinical Dermatology, 21, pp. 783–798.RI Drug and Food Supervisory Body. Composition. Abrocitinib.National Institutes of Health (2023). Medline Plus. Abrocitinib.Mayo Clinic (2023). Drugs & Supplements. Abrocitinib (Oral Route).Drugs (2022). Abrocitinib.Drugs (2022). Abrocitinib Pregnancy and Breastfeeding Warnings.Medscape. Abrocitinib (Rx).MMS Indonesia. Abrocitinib.WebMD. Abrocitinib 200 Mg Tablet - Uses, Side Effects, and More.